Complex diseases such as cancer or diabetes generally not result from mutations or malfunctions of individual molecules but from dysfunction of relevant networks. Thus, it is of great importance to analyze molecular mechanisms of the diseases on a network basis. Although classical medicine based on molecular biology has made significant progress in general, current methodologies, which are still mainly based on studying individual genes and proteins, are not good enough to solve increasing problems of complex diseases. Therefore, innovative methodologies and techniques from the perspectives of systems biology are strongly demanded to be applied for designing and searching for new medical solutions for preventing, diagnosing, and curing the diseases. Bio-network medicine is such an area to study complex diseases by a network-based approach at the molecular level, and is considered as a powerful method to assist the effective diagnosis, prognosis, and treatment …